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The Orthopaedic Mechanobiology Lab

Part of the Joint Department of Biomedical Engineering at NC State and UNC-Chapel Hill

The Orthopaedic Mechanobiology Laboratory, OML, is directed by Dr. Jacque Cole. The overall goal of the OML is to determine mechanisms underlying the prevalent bone deficits in various clinical conditions (e.g., stroke, obesity, aging, and nerve injury), with the long-term goal of developing novel therapies to treat or even prevent bone loss in these scenarios.

We characterize changes in the structure and function of bone, muscle, and vascular tissues and cells using high resolution computed tomography, materials characterization techniques (e.g., Raman spectroscopy, mechanical testing), and microscopy. Our work lies at the nexus of regenerative medicine and rehabilitation engineering, determining the factors that lead to degenerated bone tissue and then developing new strategies to restore not only tissue properties but also overall musculoskeletal function.

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