Previous Research


Examining Bone Vasculature using a Stroke Model (opens new page)

Musculoskeletal Aging (collaboration with Dr. Gregory Sawicki)

Tension Band Wiring Configurations for Stable Bone Fracture Fixation (collaboration with Dr. Simon Roe)

Meniscus for Improved Allograft Replacements (collaboration with Drs. Jeffrey Spang, Elizabeth Loboa, and Matthew Fisher)


Musculoskeletal Aging

In collaboration with Dr. Gregory Sawicki, Mechanical Engineering, Georgia Institute of Technology

Musculoskeletal performance declines with aging, leading to conditions of sarcopenia and osteopenia, but underlying mechanisms for how they are related are poorly understood. We characterize tissue properties (in situ muscle stimulator, mechanical testing) and cellular interactions (co-culture) in a rat model to improve understanding of how age-related changes in musculoskeletal function may arise from cellular crosstalk.

Publications and Presentations:

  • Doering J, Britt C, Cole J (2018) Understanding muscle-bone cellular crosstalk in aging. 8th World Congress of Biomechanics, Dublin, Ireland, Jul 8-12, Oral #O0172.
  • Doering JA and Cole JH (2018) Optimizing a cell co-culture system to understand bone-muscle crosstalk. Orthopaedic Research Society Annual Meeting, New Orleans, LA, Mar 10-13, Poster #1549.

Testing Tension Band Wiring Configurations
for Stable Bone Fracture Fixation

In collaboration with Dr. Simon Roe (Professor of Orthopaedics, College of Veterinary Medicine, NCSU)

Tension Band Wiring is used for surgical fixation of bone fractures in sites with large tensile forces, such as the greater trochanter (femur) or olecranon (ulna). This technique converts applied muscle/tendon/ligament tensile forces into compressive forces that minimize the fracture gap and promote healing and is commonly used in veterinary surgery.  We are designing a better fixture system to isolate wire properties during mechanical testing and then testing different wiring configurations to determine an optimum one for trochanteric fracture fixation in veterinary patients. Our goal is to identify appropriate mechanical properties — such as yield point (defined by loss of initial wiring tension) and failure load — with cyclic loading that mimics clinical loading patterns. Comparing this information across wiring configurations will provide insight into the best techniques to use during treatment of veterinary fractures.


Publications and Presentations:

  • Thompson E*, Robe RK*, Roe SC, Cole JH (2020). Influence of wire configuration on resistance to fragment distraction of tension bands placed in a greater trochanteric osteotomy model. Veterinary Surgery 49(4):710-718. DOI: 10.1111/vsu.13350. PMID: 31713901. * co-first authors
  • Thompson E*, Roe SC, Robe AK, Cole JH (2016) Comparison of multiple tension band wire configurations on a greater trochanteric osteotomy model. American College of Veterinary Surgeons Surgery Summit, Seattle, WA, October 6-8. * 2nd Place, Small Animal Residents’ Forum Presentation, One AO Award

Testing Meniscus for Improved Tissue Engineering of Allograft Replacements

In collaboration with Drs. Jeffrey Spang (Orthopaedic Surgery, University of North Carolina), Elizabeth Loboa (Dean of Engineering, University of Missouri), and Matthew Fisher (Biomedical Engineering, UNC/NC State)

Meniscal tears are the most common knee injury. The meniscus does not repair well, and partial or complete surgical removal can be detrimental due to increased contact stresses. Current allograft replacements must be improved to mimic native tissue both biologically and mechanically. In collaboration with Dr. Elizabeth Loboa, we are measuring the material properties of various engineered tissues to determine the best replacement.

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Publications and Presentations:

  • Nordberg RC, Charoenpanich A, Vaughn CE, Fisher MB, Cole JH, Spang JT, Loboa EG (2016) A needle-punch method to enhance cellular infiltration of adipose stem cells in allograft menisci. Biomedical Engineering Society Annual Meeting, Minneapolis, MN, October 5-8, poster.
  • Nordberg RC, Charoenpanich A, Vaughn CE, Griffith EH, Fisher MB, Cole JH, Spang JT, Loboa EG (2016). Enhanced cellular infiltration of human adipose derived stem cells in allograft menisci using a needle-punch method. J Orthop Surg Res 11(1):132. [DOI: 10.1186/s13018-016-0467-x]. PMCID: PMC5084349.