Our undergrads have been busy the last 8 months!

• Jennifer, and Josh presented at the Spring OUR Symposium in April. Due to COVID they presented a virtual poster, and did a great job! Jennifer presented on her work with Emily: Location of Brachial Plexus Birth Injury Deferentially Affects Humeral Bone Growth. Josh presented on his collaboration with Jason: Increasing Computational Throughput of Heterogeneous Bone Tissue Models

• Annie Kate presented at the Summer OUR Symposium:

• Four of our undergrads were selected as Abrams Scholars: Annie Kate, Vince, Jennifer, and new lab member Kathryn. Annie Kate and Kathryn will be working with Sandra on her bone-on-a-chip project, Vince will continue his work with Jason, and Jennifer will continue to work with Emily. Abrams Scholars are outstanding BME undergraduate students who are selected to receive a stipend to conduct hands-on laboratory research projects. These projects are conceived and designed by the students with the guidance of a faculty mentor. The Abrams Scholar program honors C. Frank Abrams, Jr., a BME and BAE emeritus faculty member. Dr. Abrams led the development of the first courses in Biomedical Engineering at NC State and was instrumental in the founding of NC State’s BME Department, the creation of the joint UNC-CH/NC State graduate program, and ultimately the launch of the UNC-CH/NC State Joint BME Department. He was the Joint Department’s first senior design instructor as well as the first Director of Graduate Studies.

• Four of our undergrads were awarded OUR grants: Vince and Jennifer for the fall semester and Annie Kate and Deeqa for spring 2021.Vince’s project, Optimizing finite element analysis of cancelous bone through microdamage simulation, will support his project working with Jason. Jennifer will continue her work on the BPBI project: Effects of BPBI on humeral bone metabolism. Deeqa will also work on the BPBI project: Effect of BPBI on muscle-bone crosstalk. Annie Kate will be working with Sandra: Examining bone-vascular interactions post-stroke using a bone-on-chip platform.

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Congratulations to Carly, Josh, and new lab member Jennifer Potts, who were both selected as Abrams scholars for the 2019-2020 academic year.

Carly will be working with Sandra on the OV project:

Assessing functional recovery following ischemic stroke: Following stroke, hip fractures occur 2-4 times more frequently than with typical aging, yet bone health is not typically monitored during rehabilitation. Stroke may alter osteovascular (within bone) circulation, which is essential for bone maintenance, and thus may contribute to the bone loss. Exercise stimulates vascular formation and improves balance and musculoskeletal strength and thus may at least partially offset the negative impacts of stroke. Conversely, bedrest during recovery may exacerbate bone loss and could have detrimental effects on vascular function. The goal of this project is to measure blood flow in the tibia following ischemic stroke in mice, and to monitor functional recovery throughout the experiment. Blood flow will be measured weekly in the tibia with a minimally invasive laser Doppler flowmetry procedure. Functional recovery will be quantified with a behavior test and with high-speed video assessment of gait kinematics.

 

Josh will be continuing his work with Jason:

Effects of tissue heterogeneity on vertebral bone mechanical properties: This project will involve creating (with guidance) finite element models of human vertebral bone using the cancellous bone architecture from micro-computed tomography scans. The micro-CT scans also provide an accurate, 3D representation of tissue mineral density throughout the bone volume, which can readily be converted into elastic modulus values using experimentally derived density-modulus relationships. The goal is to create high-resolution bone models with realistic heterogeneous material properties and then use the models to determine how mineral heterogeneity impacts the overall mechanical performance of vertebral bone. This information is especially important, given that the heterogeneity of bone changes with aging and with certain drug treatments and thus may be an important metric to monitor or target.

 

Jennifer will be working with Emily on the BPBI Project:

Bone formation and mineralization following brachial plexus birth injury: Brachial plexus birth injury (BPBI) is the most common nerve injury in children, occurring during difficult childbirth. It causes muscle paralysis, deformities in the humerus and scapula as they grow, and lifelong impairment of arm function. Little is known about the bone growth and mineralization that may contribute to the advancement and persistence of BPBI-related impairments. The project will examine changes in cortical bone growth (e.g., mid-diaphysis of the humerus) using dynamic histomorphometry. Specific tasks will include embedding bone, sectioning, and analyzing images. Results from this project will help us determine underlying changes in bone formation and mineralization with BPBI, which will inform the development of future treatments to mitigate joint deformities and maintain arm function.

 

About the Abrams Scholars Program:

Abrams Scholars are outstanding BME undergraduate students who are selected to receive a stipend to conduct hands-on laboratory research projects. These projects are conceived and designed by the students with the guidance of a faculty mentor. The Abrams Scholar program honors C. Frank Abrams, Jr., a BME and BAE emeritus faculty member. Dr. Abrams led the development of the first courses in Biomedical Engineering at NC State and was instrumental in the founding of NC State’s BME Department, the creation of the joint UNC-CH/NC State graduate program, and ultimately the launch of the UNC-CH/NC State Joint BME Department. He was the Joint Department’s first senior design instructor as well as the first Director of Graduate Studies.

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Lab member Sara recently presented an update on her research with Nicholas at the NC State Undergraduate Research Symposium annual conference. Great job Sara

!

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Sophie received the BME Department’s Undergraduate Researcher of the Month award. It was “In recognition of her outstanding research on unloading contributions to brachial plexus birth injury in the Orthopaedic Mechanobiology Laboratory”.

Congratulations Sophie!

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Josh and Carly recently presented their work at the State of North Carolina Undergraduate Research and Creativity Symposium (SNCURS, for short). The symposium is open to all undergraduate students enrolled in North Carolina colleges, universities and community colleges. The symposium is intended to showcase multidisciplinary undergraduate research scholarship. More info and photos can be found here: https://projects.ncsu.edu/sncurcs/

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Congratulations to our MANY amazing undergrads, several of whom were awarded Abrams Scholars Awards:

• Carly: Designing a hind-limb unloading apparatus to mimic disuse following stroke
• Marci: Effect of ischemic stroke on skeletal muscle structure and muscle-bone cellular crosstalk
• Josh: Effects of tissue heterogeneity on vertebral bone mechanical properties
• Maggie: Effect of Brachial Plexus Birth Injury on muscle structure and muscle-bone cellular crosstalk

And we got a new student!

• Sara Chopra: Characterizing bone vascular environment post-stroke

**UPDATE, MAY 2019** We got a great photo of the group after doing their final presentations. Great job guys!

 

About the Abrams Scholars Program:

Abrams Scholars are outstanding BME undergraduate students who are selected to receive a stipend to conduct hands-on laboratory research projects. These projects are conceived and designed by the students with the guidance of a faculty mentor. The Abrams Scholar program honors C. Frank Abrams, Jr., a BME and BAE emeritus faculty member. Dr. Abrams led the development of the first courses in Biomedical Engineering at NC State and was instrumental in the founding of NC State’s BME Department, the creation of the joint UNC-CH/NC State graduate program, and ultimately the launch of the UNC-CH/NC State Joint BME Department. He was the Joint Department’s first senior design instructor as well as the first Director of Graduate Studies.

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Congratulations to Maggie, who was awarded an OUR (Office of Undergraduate Research) grant. This grant contributes $1000 toward supplies for her project. Her proposal title is “The Effect of Brachial Plexus Birth Injury on Muscle Structure and Muscle-Bone Cellular Crosstalk”.

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Maggie and Carly recently presented their research at the Summer Undergraduate Research Symposium at NC State.

Great job to both of you!

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Maggie presented a poster on the rat forelimb unloading project that she and Sophie as working on at the Annual Undergraduate Research Symposium earlier today. She did a great job explaining the project’s motivation and initial results!

UPDATE: Maggie won an award for her poster! Sigma Xi, the Scientific Research Society, named it one of the outstanding presentations at this year’s Undergraduate Research Symposium. See the award announcement here.

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Congratulations to Hannah, Sophie, and Maggie! Their abstracts have been accepted for poster presentations at the National Conference on Undergraduate Research, which will be at the University of Central Oklahoma in April. Great job, guys!

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